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2,6-Dimethylaniline

2,6-Dimethylaniline Structure
2,6-Dimethylaniline
  • CAS No.87-62-7
  • Chemical Name:2,6-Dimethylaniline
  • CBNumber:CB8327518
  • Molecular Formula:C8H11N
  • Formula Weight:121.18
  • MOL File:87-62-7.mol
2,6-Dimethylaniline Property
  • Melting point: :10-12 °C(lit.)
  • Boiling point: :216 °C
  • Density  :0.984 g/mL at 25 °C(lit.)
  • vapor pressure  :<0.01 mm Hg ( 20 °C)
  • refractive index  :n20/D 1.560(lit.)
  • Flash point: :196 °F
  • storage temp.  :Store below +30°C.
  • solubility  :13g/l
  • form  :Liquid
  • pka :3.89(at 25℃)
  • color  :Clear yellow to red-brown
  • PH Range :12.5
  • PH :12.5 (100g/l, H2O, 20℃)
  • explosive limit :1.3-6.9%(V)
  • Water Solubility  :7.5 g/L (20 ºC)
  • Merck  :14,10084
  • BRN  :636332
  • CAS DataBase Reference :87-62-7(CAS DataBase Reference)
  • EWG's Food Scores :4-5
  • FDA UNII :4FT62OX08D
  • Proposition 65 List :2,6-Xylidine (2,6-Dimethylaniline)
  • NIST Chemistry Reference :Benzenamine, 2,6-dimethyl-(87-62-7)
  • IARC :2B (Vol. 57) 1993
  • EPA Substance Registry System :2,6-Xylidine (87-62-7)
Safety
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H227-H319-H361-H370-H371-H373-H302+H312+H332-H315-H335-H351-H411-H302-H312-H332-H401
  • Precautionary statements P262-P280h-P261-P280-P301+P312+P330-P273-P201-P202-P210-P260-P264-P270-P271-P302+P352+P312+P362+P364-P304+P340+P312-P305+P351+P338+P337+P313-P307+P311-P370+P378-P391-P403+P233-P405-P501
2,6-Dimethylaniline Price More Price(21)
  • Brand: Sigma-Aldrich
  • Product number: 442327
  • Product name : 2,6-Dimethylaniline
  • Purity: analytical standard
  • Packaging: 1000 mg
  • Price: $16.2
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 8.08671
  • Product name : 2,6-Dimethylaniline
  • Purity: for synthesis
  • Packaging: 5 mL
  • Price: $19.7
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: D146005
  • Product name : 2,6-Dimethylaniline
  • Purity: 99%
  • Packaging: 5g
  • Price: $20.6
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 36766
  • Product name : 2,6-Dimethylaniline
  • Purity: PESTANAL , analytical standard
  • Packaging: 1g-r
  • Price: $38.4
  • Updated: 2020/08/18
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 36766
  • Product name : 2,6-Dimethylaniline
  • Purity: PESTANAL?, analytical standard
  • Packaging: 250MG-R
  • Price: $39.9
  • Updated: 2021/03/22
  • Buy: Buy

2,6-Dimethylaniline Chemical Properties,Usage,Production

  • Chemical Properties clear yellow to red-brown liquid
  • Uses Bupivacaine (B689560) impurity.
  • Definition ChEBI: A primary arylamine that is aniline in which the hydrogens at the 2- and 6-positions are replaced by methyl groups. It is used in the production of some anasthetics and other chemicals. It is a drug metabolite of lidocaine (local anasthetic).
  • Synthesis Reference(s) Journal of the American Chemical Society, 92, p. 7464, 1970 DOI: 10.1021/ja00728a038
    The Journal of Organic Chemistry, 37, p. 3570, 1972
  • General Description A liquid. Toxic by ingestion, inhalation and skin absorption. Slightly soluble in water. Used in pharmaceuticals, as dye intermediates and organic syntheses.
  • Air & Water Reactions Slightly soluble in water.
  • Reactivity Profile 2,6-Dimethylaniline reacts with strong oxidizing agents [Handling Chemicals Safely 1980 p. 964]. Neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
  • Health Hazard May be fatal if inhaled, swallowed or absorbed through skin. Vapor or mist irritating to the eyes, mucous membranes and upper respiratory tract; causes skin irritation. Absorption into body leads to the formation of methemoglobin which, in sufficient concentration, may cause cyanosis. Onset may be delayed 2-4 hours or longer. Exposure can cause nausea, dizziness, headache, damage to the eyes, and blood effects.
  • Fire Hazard Special Hazards of Combustion Products: Container explosion may occur under fire conditions. Emits toxic fumes under fire conditions.
  • Safety Profile Suspected carcinogen. Moderately toxic by ingestion. Mutation data reported. Questionable carcinogen with experimental carcinogenic data. When heated to decomposition it emits toxic fumes of NOx. See also other xylidme entries.
  • Purification Methods Convert vic-xylidine to a derivative (see below) which, after recrystallisation, is decomposed with alkali to give the free base. Dry it over KOH and fractionally distil. The acetyl derivative has m 177o, the benzoyl derivative has m 168o, and the picrate has m 180o. [Beilstein 12 H 1107, 12 IV 2521.]
2,6-Dimethylaniline Preparation Products And Raw materials
Raw materials
Preparation Products
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87-62-7, 2,6-DimethylanilineRelated Search:
  • 2,6-Xylidine, 2-Amino-m-xylene
  • 2,6-Dimethylaniline Solution, 100ppm
  • 2,6-two Methyl aniline
  • 2.6-DiMethylan
  • ai3-52358
  • Aniline, 2,6-dimethyl-
  • NCI-C56188
  • 2,6-Dimethylaniline (Lidocaine RCA)
  • AKOS BBS-00003564
  • 1-Amino-2,6-dimethylbenzene
  • 2,6-dimethyl-anilin
  • Bupivacaine EP Impurity F(Lidocaine EP Impurity A)
  • Lidocaine EP impurity A
  • Bupivacaine Impurity 8(EP Impurity F)
  • Mepivacaine Impurity 1(Mepivacaine EP Impurity A)
  • DIMETHYLANILINE,2,6-
  • TIMTEC-BB SBB008136
  • VIC-M-XYLIDINE
  • xylylamine
  • 6-Amino-m-xylene
  • 2,6-XYLIDINE
  • 2,6-DIMETHYLANILINE
  • 2-AMINO-1,3-DIMETHYLBENZENE
  • 2-AMINO-M-XYLENE
  • LABOTEST-BB LTBB000551
  • 2,6-DIMETHYLANILINE, 1ML, NEAT
  • 2,6-DIMETHYLANILINE, 1000MG, NEAT
  • 2,6-DIMETHYLANILINE PESTANAL
  • Lidocaine Related Compound A
  • Mepivacaine EP Impurity A
  • Ropivacaine EP Impurity H
  • Xylazine EP Impurity A
  • Lidocaine Impurity 5
  • 2,6-Dimethylaniline 2,6-xylidine from fandachem
  • Lidocaine BP Impurity A
  • 2,6-Xylidine (NH2=1)
  • Benzenamine, 2,6-dimethyl-
  • amino-p-xylol
  • 2,6-DIMETHYLBENZAMINE
  • 2,6-Xylidine, 2-Amino-1,3-dimethylbenzene
  • 2,6-xylidine 2,6-dimethylaniline
  • 2,6-DIMETHYLANILINE pure
  • 2,6-Xylidine, 2-Amino-1,3-dimethylbenzene, 2-Amino-m-xylene
  • 2,6-dimethyl-benzenamin
  • 2,6-Dimethylbenzenamine
  • 2,6-dimethyl-Benzenamine
  • 2,6-Dimethylbenzeneamine
  • 2,6-dimethylphenylamine
  • 2,6-Dimethyl-phenylamine
  • 2,6-DMA
  • 2,6-Xyildine
  • 2,6-Xylylamine
  • 2-amino-1,3-dimethyl-benzen
  • 2-Amino-1,3-xylene
  • 2,6XylidinePure
  • 2,6-Xylidine99%
  • 2,6-Dimethylaniline,99%
  • 2.6-Dimethylaniline 5g [87-62-7]