Description
CeMMEC1 is an N-methylisoquinolinone that inhibits the second bromodomain of TAF1 (K
d = 1.8 μM; IC
50 = 0.9 μM). It does not bind to either the first or second bromodomain of BRD4. This compound synergizes with (+)-JQ1 to inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells.
Uses
CeMMEC1, shows high affinity for TAF1, and is an inhibitor of BRD4.
References
[1] SARA SDELCI. Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk[J]. Nature chemical biology, 2016, 12 7: 504-510. DOI:
10.1038/nchembio.2080
