440662-09-9

CeMMEC1 is an N-methylisoquinolinone that inhibits the second bromodomain of TAF1 (K_d = 1.8 μM; IC₅₀ = 0.9 μM). It does not bind to either the first or second bromodomain of BRD4. This compound synergizes with (+)-JQ1 to inhibit the proliferation of THP-1 and H23 lung adenocarcinoma cells.

CeMMEC1, shows high affinity for TAF1, and is an inhibitor of BRD4.

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[1] SARA SDELCI. Mapping the chemical chromatin reactivation landscape identifies BRD4-TAF1 cross-talk[J]. Nature chemical biology, 2016, 12 7: 504-510. DOI: 10.1038/nchembio.2080