Description
Cooenzyme Q
10 (CoQ
10) is a component of the electron transport chain and participates in aerobic cellular respiration, generating energy in the form of ATP. CoQ
1 is an amphipathic CoQ
10 homolog that has a tail consisting of five isoprene units. It has been used as an electron acceptor to study a range of oxidoreductases as isolated enzymes, in subcellular fractions, in intact cells in culture, and in perfused organs. Ubiquinone analogs, including CoQ
1, impact mitochondrial permeability transition pore (PTP) formation, as well as PTP-dependent cell death, in an analog- and cell-specific manner.
Uses
Coenzyme Q1 has been used to measure the mitochondrial respiratory chain complex 1 activity.
Uses
Coenzyme Q1 is an electron acceptor and a component of the electron transport chain. It also play a role in themitochondrial permeability transition pore (PTP). Coenzyme Q1 is structurally similar tocoenzyme Q2 (C636450)andcoenzyme Q10 (C636501).
Definition
ChEBI: Ubiquinones is any benzoquinone derived from 2,3-dimethoxy-5-methylbenzoquinone; one of a group of naturally occurring homologues. The redox-active quinoid moiety usually carries a polyprenoid side chain at position 6, the number of isoprenoid units in which is species-specific. Ubiquinones are involved in the control of mitochondrial electron transport, and are also potent anti-oxidants. It has a role as an Escherichia coli metabolite and a mouse metabolite. It is a prenylquinone and a member of 1,4-benzoquinones. It is functionally related to a 2,3-dihydroxy-5-methyl-1,4-benzoquinone.
General Description
Coenzyme Q (CoQ) is localized to the hydrophobic domain of the phospholipid bilayer of mitochondria, plasma lipoproteins, and other biological membranes. It is a ubiquinone homolog with a short isoprenoid side chain.
Biochem/physiol Actions
Coenzyme Q1 (CoQ1) is a 1 isoprenyl group (not naturally occurring) member of a family of ubiquinones that share a quinine chemical group but differ in the number of isoprenyl chemical subunits in their tail. The CoQ compounds are lipid soluble components of cell membranes where they perform multiple functions such as electron and proton transport. The most well studied CoQ compound is CoQ10. CoQ1 is frequently used in comparison studies on the effect of isoprenyl chain length on CoQ functions or distribution and to identify quinone reductases.
References
[1] ROMANA FATO. Steady-State Kinetics of the Reduction of Coenzyme Q Analogs by Complex I (NADH:Ubiquinone Oxidoreductase) in Bovine Heart Mitochondria and Submitochondrial Particles[J]. Biochemistry Biochemistry, 1996, 35 8: 2705-2716. DOI:
10.1021/bi9516034[2] FLAVIEN DEVUN. Ubiquinone analogs: a mitochondrial permeability transition pore-dependent pathway to selective cell death.[J]. PLoS ONE, 2010: e11792. DOI:
10.1371/journal.pone.0011792[3] ROBERT D BONGARD. Coenzyme Q(1) as a probe for mitochondrial complex I activity in the intact perfused hyperoxia-exposed wild-type and Nqo1-null mouse lung.[J]. American journal of physiology. Lung cellular and molecular physiology, 2012: L949-58. DOI:
10.1152/ajplung.00251.2011
