Chemical Properties
Crystalline powder
Uses
3-Methoxy-5-methylphenol (cas# 3209-13-0) is a compound useful in organic synthesis.
Definition
ChEBI: 3-Methoxy-5-methylphenol is a member of phenols and a member of methoxybenzenes.
Synthesis Reference(s)
Organic Syntheses, Coll. Vol. 6, p. 859, 1988
The Journal of Organic Chemistry, 49, p. 1672, 1984
DOI: 10.1021/jo00183a043Tetrahedron Letters, 11, p. 1327, 1970
Synthesis
A solution of anhydrous orcinol (12.4 g,0.1 mole) in dry acetone (100 ml)is refluxed for 4 hr with dimethyl sulphate (10.63 ml，14.2 g,0.112 mole) and ignited potassium carbonate (20 g) under anhydrous conditions. The mixture is filtered in hot, and the inorganic salts are washed with hot acetone(25 ml). The combined acetone solution is distilled. The oily product is purified by column chromatography over silica gel using chloroform as aneluant. Orcinol monomethyl ether is obtained as oil. Yield 4.2 g (30.4%).
