4-[2-(2-Hydroxy-3,5-dimethylphenyl)-2-oxoethyl]piperidine-2,6-dione

Uses

Actiphenol is an antibiotic against coxsackievirus B3 and influenza A virus (IC50s = 14.37 and 34.4 μg/mL, respectively). Actiphenol is also an aromatic ketone that exhibits weak eukaryotic translation inhibiton activity, which is found in Streptomyces species. Actiphenol can be used as a key intermediate to synthesize Cycloheximide (HY-12320)[1][2].

Definition

ChEBI: Actiphenol is an aromatic ketone.

References

[1] Ji XY, et al. Synthesis and antiviral activities of synthetic glutarimide derivatives. Chem Pharm Bull (Tokyo). 2010 Nov;58(11):1436-41. DOI:10.1248/cpb.58.1436
[2] Yin M, et al. Cycloheximide and actiphenol production in Streptomyces sp. YIM56141 governed by single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase. Org Lett. 2014 Jun 6;16(11):3072-5. DOI:10.1021/ol501179w