Description
Lysophosphatidylethanolamine (LPE) is a naturally-occurring lysophospholipid that can be generated
via deacylation of phosphatidylethanolamine by phospholipase A
2 (PLA
2). It increases the phosphorylation of ERK1/2 in PC12 cells, an effect that can be blocked by the MEK inhibitors U-0126 and PD 98059 and the EGFR inhibitor AG-1478 . LPE also increases neurite outgrowth and expression of neurofilament M in PC12 cells. LPE inhibits the activity of phospholipase D (PLD) partially purified from cabbage. Lysophosphatidylethanolamines (egg) is a mixture of lysophosphatidylethanolamines isolated from chicken egg with fatty acyl groups of variable lengths at the
sn-1 position and a hydroxy group at the
sn-2 position.
Uses
Lysophosphatidyletha?nolamines, Egg is a natural Glycerophospholipid. Glycerophospholipids act as regulators of various enzyme activities, and can be used as biological markers to indicate pathological states.
Definition
ChEBI: 1-stearoyl-sn-glycero-3-phosphoethanolamine is a 1-acyl-sn-glycero-3-phosphoethanolamine in which the acyl group is specified as stearoyl. It has a role as a human metabolite. It is a 1-acyl-sn-glycero-3-phosphoethanolamine and a lysophosphatidylethanolamine 18:0. It is functionally related to an octadecanoic acid. It is a tautomer of a 1-stearoyl-sn-glycero-3-phosphoethanolamine zwitterion.
