Chemical Properties
dark red-purple crystalline powder
Uses
A blocker of transmembrane Ca
2+ fluxes (IC
50 = 7 µM) that attenuates capsaicin-induced cation channel opening. Inhibits Ca
2+-induced Ca
2+ release from ryanodine-sensitive intracellular Ca
2+ stores. Inhibits K
+-stimulated catecholamine secretion (IC
50 = 6 µM).
Biological Activity
Cell permeable: no', 'Primary Target
Blocker of transmembrane Ca2+ fluxes', 'Product does not compete with ATP.', 'Reversible: no', 'Target IC50: 7 μM in blocking transmembrane Ca2+ fluxes; 6 μM inhibiting K+-stimulated catecholamine secretion
