Synthesis
General procedure for the synthesis of 2-bromo-4'-(trifluoromethyl)acetophenone using 1-(bromoethynyl)-4-(trifluoromethyl)benzene as starting material: a mixed solution of haloalkynes (0.5 mmol), silver fluoride (5 mol%), and water (1 eq.) in trifluoroacetic acid (1 mL) was stirred for 6 hours at 40 °C. Upon completion of the reaction, the trifluoroacetic acid was recovered by distillation for reuse. The residue was purified by column chromatographic separation to afford the target product 2-bromo-4'-(trifluoromethyl)acetophenone.
References
[1] Tetrahedron Letters, 2014, vol. 55, # 7, p. 1373 - 1375
[2] European Journal of Organic Chemistry, 2016, vol. 2016, # 1, p. 116 - 121
[3] Tetrahedron, 2016, vol. 72, # 27-28, p. 3818 - 3822
[4] Tetrahedron Letters, 2016, vol. 57, # 45, p. 4983 - 4986
[5] Chinese Journal of Chemistry, 2016, vol. 34, # 12, p. 1251 - 1254
