Description
Ethylenebis(oxyethylenenitrilo)tetraacetic acid is also named as Egtazic acid. It works as a chelating agent for the determination of calcium in the presence of magnesium.
Chemical Properties
White to slightly off-white powder
Uses
A chelating agent useful for the determination of calcium in the presence of magnesium.
Uses
Ethylene glycol-O,O'-bis(2-aminoethyl)-N,N,N',N'-tetraacetic acid is a chelating agent used for making complexes, especially for calcium ions, which help to determine calcium in the presence of magnesium. It can be used experimentally for treating animals possessing cerium poisoning. It is useful in the separation of thorium from monazite. It also acts as a buffer and is used in protein purification.
Uses
Pharmaceutic aid. EGTA.
Definition
ChEBI: A diether that is ethylene glycol in which the hydrogens of the hydroxy groups have been replaced by 2-[bis(carboxymethyl)amino]ethyl group respectively.
Biological Activity
Calcium chelator; protects against cell death caused by nitric oxide-induced calcium influx into nerve cells.
Safety Profile
Poison by
intraperitoneal route. Moderately toxic by
ingestion. When heated to decomposition it
emits toxic fumes of NOx. See also
GLYCOL ETHERS.
Purification Methods
Dissolve EGTA in aqueous NaOH, precipitate it by adding aqueous HCl, wash it with water and dry at 100o in vacuo.[Beilstein 4 IV 217.]
