Description
tetranor-
PGEM is the major urinary metabolite of PGE
1 and PGE
2, and is used as a marker of PGE
2 biosynthesis. About 15% of an infused dose of PGE
2 appears as this metabolite in the urine of humans. Normal healthy males excrete 7-
40 μg of tetranor-
PGEM over a 24-
hour period.
Definition
ChEBI: A prostanoid that is prostaglandin E2 in which the acyclic hydroxy group has been oxidised to the corresponding ketone, the methyl group has been oxidised to the corresponding carboxylic acid and the 6-carboxyhexenyl group has been oxidatively cleaved to a
2-carboxyethyl group. It is the major urinary metabolite of prostaglandin E2.
