Rimonabant-d10

Uses

Rimonabant-d10 is deuterium labeled Rimonabant. Rimonabant (SR141716) is a highly potent, brain penetrated and selective central cannabinoid receptor (CB1) antagonist with a Ki of 1.8 nM. Rimonabant (SR141716) also inhibits Mycobacterial membrane protein Large 3 (MMPL3).

Biological Activity

Rimonabant-d10 contains 10 deuterium atoms at the 2, 2', 3, 3', 4, 4', 5, 5', 6, and 6' positions. It is intended for use as an internal standard for the quantification of rimonabant by GC- or LC-MS. Rimonabant, also known as SR141716, was the first selective central cannabinoid (CB1) receptor inverse agonist (Ki = 1.8 nM) to be developed as an appetite suppressant and anti-obesity drug.1 It is widely used as a tool to investigate CB receptor properties and the mechanisms by which CB agonists exert their pharmacological effects.

References

1.Rinaldi-Carmona, M., Barth, F., Héaulme, M., et al.SR141716A, a potent and selective antagonist of the brain cannabinoid receptorFEBS Letters350(2-3)240-244(1994)