Description
FDP is used as a fluorogenic alkaline phosphatase substrate. Alternatively, it can also be used to detect phosphatases in a chromogenic mode since the enzymatic product (fluorescein) exhibits a large extinction coefficient (close to 100,000 cm-1mol-1).
Chemical Properties
Sodium fructose 1,6-diphosphate is white or off-white crystalline powder, easy to flow, very easy to absorb moisture. Easily soluble in water, insoluble in organic solvents such as ethanol. Slightly fragrant, slightly salty taste, dry product is stable at room temperature.1,6-Diphosphofructose is an important intermediate product in the process of glucose metabolism in the human organism, and is a metabolic regulator at the molecular level. Its trisodium salt, i.e. this product, can regulate the activity of several enzymes in glucose metabolism, increase the concentration of intracellular adenosine triphosphate and phosphocreatine, promote the inward flow of potassium ions, increase the content of diphosphoglyceric acid in erythrocytes, and inhibit the release of oxygen radicals and histamine, and it can alleviate the tissue damage due to ischemia and hypoxia, especially for ischemic myocardium, which has shown a good protective effect. Intravenous injection, plasma half-life of 10-15min, it is distributed from the blood to tissues outside the blood circulation, hydrolyzed by phosphatase into phosphoric acid and fructose, and a small portion of it is excreted from the urine.
