Description
Loganic acid is an iridoid glycoside that has been found in
C. mas and has diverse biological activities, including antidiabetic, antiadipogenic, anti-atherosclerotic, and anti-inflammatory properties. Loganic acid (1 μM) stimulates glucagon-like peptide-1 (GLP-1) secretion by NCI H716 human enteroendocrine colorectal cancer cells. It inhibits dexamethasone-, 3-isobutyl-1-methylxanthine-, and insulin-induced differentiation of mouse 3T3-L1 fibroblasts into adipocytes when used at a concentration of 10 μg/ml. Loganic acid (20 mg/kg per day) decreases the plasma atherogenic index, a ratio of triglyceride to HDL cholesterol, and the cardiac risk ratio, a ratio of total cholesterol to HDL cholesterol, in a rabbit model of atherosclerosis induced by a cholesterol-rich diet. It also decreases IL-6, TNF-α, and oxidized LDL (oxLDL) plasma levels in the same model.
Chemical Properties
Off-white crystalline powder, soluble in methanol, derived from Gentiana macrophylla.
Uses
Loganic Acid is found to be present in both the fermented fruits and brines. Exhibits antioxidant activity.
Definition
ChEBI: A cyclopentapyran that is 1,4a,5,6,7,7a-hexahydrocyclopenta[c]pyran-4-carboxylic acid substituted at positions 1, 6 and 7 by beta-D-glucosyloxy, hydroxy and methyl groups respectively
References
[1] CARMINE J. COSCIA Luigi B Rocco Guarnaccia. Monoterpene biosynthesis. I. Occurrence and mevalonoid origin of gentiopicroside and loganic acid in Swertia caroliniensis[J]. Biochemistry Biochemistry, 1969, 8 12: 5036-5043. DOI:
10.1021/bi00840a054[2] HYO-WEON SUH . A bitter herbal medicine Gentiana scabra root extract stimulates glucagon-like peptide-1 secretion and regulates blood glucose in db/db mouse[J]. Journal of ethnopharmacology, 2015, 172: Pages 219-226. DOI:
10.1016/j.jep.2015.06.042[3] EUNKUK PARK. Antiadipogenic Effects of Loganic Acid in 3T3-L1 Preadipocytes and Ovariectomized Mice.[J]. Molecules, 2018, 23 7. DOI:
10.3390/molecules23071663[4] TOMASZ SOZASKI . Iridoid–loganic acid versus anthocyanins from the Cornus mas fruits (cornelian cherry): Common and different effects on diet-induced atherosclerosis, PPARs expression and inflammation[J]. Atherosclerosis, 2016, 254: Pages 151-160. DOI:
10.1016/j.atherosclerosis.2016.10.001
