Description
Novel and non-ODS-based (ODS = ozone-depleting substance) difluorocarbene reagents for O- and
N-difluoromethylation. PhCOCF2Cl reacts with a variety of structurally diverse phenol derivatives to
produce aryl difluoromethyl ethers in good yields. PhSO2CF2Cl can react with a variety of structurally
diverse phenol derivatives and N-heterocyclic compounds.
General Description
2-Chloro-2,2-difluoroacetophenone is a difluorocarbene reagent, which is generally used in the synthesis of 2,2-difluoro enol silyl ethers, and
gem?-difluoromethene derived compounds.