Description
Prostaglandin H
2 (PGH
2) was first isolated from incubations of arachidonic acid with ovine seminal vesicle microsomes, and was described as a potent vasoconstrictor. PGH
2 is the precursor for all 2-
series PGs and thromboxanes (TXs), and is a TP receptor agonist which irreversibly aggregates human platelets at 50-
100 ng/ml.
Uses
PGH2 (Prostaglandin H2) is a thromboxane A2 precursor and a platelet aggregator of vascular smooth muscle contraction.
Definition
ChEBI: Prostaglandin H2 is an oxylipin, an olefinic compound, a secondary alcohol and a prostaglandins H. It has a role as a mouse metabolite. It is a conjugate acid of a prostaglandin H2(1-).
References
[1] M HAMBERG. Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation.[J]. Proceedings of the National Academy of Sciences of the United States of America, 1974, 71 2: 345-349. DOI:
10.1073/pnas.71.2.345[2] KATEINA MACáKOVá . In vitro platelet antiaggregatory properties of 4-methylcoumarins[J]. Biochimie, 2012, 94 12: Pages 2681-2686. DOI:
10.1016/j.biochi.2012.09.006
