Uses
4-Bromo-2-nitroanisole serves as a starting material in a Suzuki coupling with 2-furanylboronic acid MIDA ester, catalyzed by tetrakis(triphenylphosphine)palladium(0) in the presence of sodium carbonate, to give 2-(4-methoxy-3-nitrophenyl)furan[2].
Synthesis
4-Bromo-2-nitroanisole is obtained by nitration of p-bromoanisole in aqueous acetic acid in the presence of urea, which also affords p-nitroanisole, 2,4-dibromoanisole, p-nitrophenol and 2-bromo-4-nitrophenol as accompanying products[1].
References
[1] J.M. Readman. IPSO-NITRATION
STUDIES. PhD Thesis. University of Canterbury.
[2] Discovery and Design of Next Generation Inhibitors to Targeting the HER2/HER3 Heterodimer and K-Ras.
