Description
Cyclooxygenase metabolism of EPA to produce Prostaglandin E
3 (PGE
3) has been reported in biosynthetic preparations of ovine seminal vesicles and in the ocular tissues of primates. Prostaglandin A
3 (PGA
3) is an expected non-
enzymatic dehydration product of this PGE
3. PGA
3 exhibits good affinity for the canine EP
2 and EP
4 receptors with IC
50 values of 120 nM and 20 nM, respectively, in a radioligand binding assay. PGA
3 has weak affinity for human PPARγ, with a K
i value of 188 μM.
Definition
ChEBI: Prostaglandin A3 is a member of the class of prostaglandins A that is prosta-5,10,13,17-tetraen-1-oic acid carrying oxo and hydroxy substituents at positions 9 and 15 respectively (the 5Z,13E,15S,17Z-stereoisomer). It has a role as a mammalian metabolite. It is a prostaglandins A and a secondary allylic alcohol. It is a conjugate acid of a prostaglandin A3(1-).
