36614-31-0

Cyclooxygenase metabolism of EPA to produce Prostaglandin E₃ (PGE₃) has been reported in biosynthetic preparations of ovine seminal vesicles and in the ocular tissues of primates. Prostaglandin A₃ (PGA₃) is an expected non-enzymatic dehydration product of this PGE₃. PGA₃ exhibits good affinity for the canine EP₂ and EP₄ receptors with IC₅₀ values of 120 nM and 20 nM, respectively, in a radioligand binding assay. PGA₃ has weak affinity for human PPARγ, with a K_i value of 188 μM.

ChEBI: Prostaglandin A3 is a member of the class of prostaglandins A that is prosta-5,10,13,17-tetraen-1-oic acid carrying oxo and hydroxy substituents at positions 9 and 15 respectively (the 5Z,13E,15S,17Z-stereoisomer). It has a role as a mammalian metabolite. It is a prostaglandins A and a secondary allylic alcohol. It is a conjugate acid of a prostaglandin A3(1-).