Synthesis
Under nitrogen protection, 3.77 g of p-bromochlorobenzene, 6.01 g of anhydrous K3PO4, 0.15 g of anhydrous Cu(CH3CO2)2 and 0.19 g of proline were added to a 100 mL three-necked flask. Then, 2.53 g of p-bromoaniline and 10 mL of DMF were injected using a syringe. After reacting at 130 °C for 4 h, the reaction was stopped, filtered, and most of the solvent was evaporated. The residue was diluted with distilled water and adjusted to pH 2-3. The residue was then filtered under vacuum, the filter cake was washed with ethyl acetate, and the filtrate was dried over anhydrous sodium sulfate. The solution was then concentrated under reduced pressure, and the residue was recrystallized to obtain a pale yellow solid (yield 93%, purity 99%).
Uses
Di(4-bromophenyl)amine is an amine organic compound and an important intermediate in the synthesis of pressure-sensitive dyes, pharmaceuticals, rubber, pesticides, and adhesive excipients.
