ChemicalBook CAS DataBase List Foralumab

Foralumab

Product NameForalumab
CAS946415-64-1
CBNumberCB68080819
MW0
MOL FileMol file
MSDS FileSDS

Chemical Properties

form	Liquid
color	Colorless to light yellow
FDA UNII	J43DL56H6M

Foralumab Price

Product number	Packaging	Price	Product description	Buy
ChemScene CS-0612956	1mg	$282	Foralumab 98.08%	Buy
ChemScene CS-0612956	5mg	$704	Foralumab 98.08%	Buy
ChemScene CS-0612956	10mg	$1127	Foralumab 98.08%	Buy
aablocks AA0294TB	1mg	$250	Foralumab ≥95%(SDS-PAGE&SEC-HPLC)	Buy
aablocks AA0294TB	5mg	$660	Foralumab ≥95%(SDS-PAGE&SEC-HPLC)	Buy

Foralumab Chemical Properties,Usage,Production

Uses

Foralumab (NI-0401) is a potent, orally active human monoclonal antibody targeting the CD3. Foralumab modulates immune responses by human cells in NSG mice that were reconstituted with human hematopoietic stem cells[1].

in vivo

Foralumab (NI-0401; 0.6-250 μg; p.o.; daily, for 5 d) delays the rejection of B6Rag2^/ skin grafted onto the humanized mice^[1].
Foralumab (0.6-250 μg; p.o. and i.h.; daily, for 5 d) prevents skin xenograft rejection in mice with human immune systems^[1].
Foralumab (1-15 μg; p.o.; daily, for 5 d) has good bioavailability of intragastric in humanized mice^[1].

Animal Model:	Humanized NOD/SCID IL-2γc^/ mice with Skin grafts (Humanized mice: CD34+ cells are injected intra-hepatically into irradiated (0.9 Gy) NSG pups within 48 hours of birth) ^[1]
Dosage:	15 μg
Administration:	Oral administration; daily, for 5 days and weekly dosing
Result:	Showed robust protection against graft rejection and prolongs graft survival. Reduced proliferation of CD8+ T cells and reduced release of TNF. Increased the concentration of IL-10.

Animal Model:	Humanized NOD/SCID IL-2γc^/ mice with Skin grafts (Humanized mice: CD34+ cells are injected intra-hepatically into irradiated (0.9 Gy) NSG pups within 48 hours of birth) ^[1]
Dosage:	1, 5, 15, 50, and 250 μg (p.o.), 0.6 mg/kg (i.h.)
Administration:	Oral administration and subcutaneous injection; daily, for 5 days and weekly dosing
Result:	Had tolerant to autologous skin grafts in humanized mice.

Animal Model:	Humanized NOD/SCID IL-2γc^/ mice with Skin grafts (Humanized mice: CD34+ cells are injected intra-hepatically into irradiated (0.9 Gy) NSG pups within 48 hours of birth) ^[1]
Dosage:	0, 5, 10, and 15 μg
Administration:	Oral administration and subcutaneous injection; daily, for 5 days and weekly dosing
Result:	Increased human Ig on the surface of CD4+ and CD8+ T cells. Had free mAb in the serum of mice

References

[1] Ogura M, et, al. Oral treatment with foralumab, a fully human anti-CD3 monoclonal antibody, prevents skin xenograft rejection in humanized mice. Clin Immunol. 2017 Oct;183:240-246. DOI:10.1016/j.clim.2017.07.005

Preparation Products And Raw materials

Foralumab Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai YuanYe Biotechnology Co., Ltd.	18916372613	yanzihan@shyuanye.com	China	87240	60
ShangHai Biochempartner Co.,Ltd	177-54423994 17754423994	2853530910@QQ.com	China	7996	62
BOC Sciences	16314854226; +8616314854226	inquiry@bocsci.com	United States	19852	58
Taizhou Nanfeng Pharmaceutical Research Institute	nanfengpharma@126.co 18616377689	nanfengpharma@126.com	China	20000	58
Guangzhou Hongyuan Chemical Co.,Ltd	15817493340	981810490@qq.com	China	1577	58
Wuhan Chemstan Biotechnology Co., Ltd.	027-65317797 15926423062	422450190@qq.com	China	10302	58
Beijing Jin Ming Biotechnology Co., Ltd.	010-60605840	psaitong@jm-bio.com	China	27626	58
TargetMol Chemicals Inc.	4008200310 15002144251	marketing@tsbiochem.com	China	24951	58
Biolab Reagents	027-65279366 18108604356	products@biolabreagent.com	China	9864	58
Wuhan Jingkangen Biomedical Technology Co., Ltd	13720134139 086-15871494362 13720134139	orders@jknbiochem.com	China	7284	58

946415-64-1, ForalumabRelated Search

Send Inquiry