ChemicalBook CAS DataBase List 946415-64-1

946415-64-1

Name	Foralumab
CAS	946415-64-1

Chemical Properties

form	Liquid
color	Colorless to light yellow

Hazard Information

Uses

Foralumab (NI-0401) is a potent, orally active human monoclonal antibody targeting the CD3. Foralumab modulates immune responses by human cells in NSG mice that were reconstituted with human hematopoietic stem cells[1].

in vivo

Foralumab (NI-0401; 0.6-250 μg; p.o.; daily, for 5 d) delays the rejection of B6Rag2^?/? skin grafted onto the humanized mice^[1].
Foralumab (0.6-250 μg; p.o. and i.h.; daily, for 5 d) prevents skin xenograft rejection in mice with human immune systems^[1].
Foralumab (1-15 μg; p.o.; daily, for 5 d) has good bioavailability of intragastric in humanized mice^[1].

Animal Model:	Humanized NOD/SCID IL-2γc^?/? mice with Skin grafts (Humanized mice: CD34+ cells are injected intra-hepatically into irradiated (0.9 Gy) NSG pups within 48 hours of birth) ^[1]
Dosage:	15 μg
Administration:	Oral administration; daily, for 5 days and weekly dosing
Result:	Showed robust protection against graft rejection and prolongs graft survival. Reduced proliferation of CD8+ T cells and reduced release of TNF. Increased the concentration of IL-10.

Animal Model:	Humanized NOD/SCID IL-2γc^?/? mice with Skin grafts (Humanized mice: CD34+ cells are injected intra-hepatically into irradiated (0.9 Gy) NSG pups within 48 hours of birth) ^[1]
Dosage:	1, 5, 15, 50, and 250 μg (p.o.), 0.6 mg/kg (i.h.)
Administration:	Oral administration and subcutaneous injection; daily, for 5 days and weekly dosing
Result:	Had tolerant to autologous skin grafts in humanized mice.

Animal Model:	Humanized NOD/SCID IL-2γc^?/? mice with Skin grafts (Humanized mice: CD34+ cells are injected intra-hepatically into irradiated (0.9 Gy) NSG pups within 48 hours of birth) ^[1]
Dosage:	0, 5, 10, and 15 μg
Administration:	Oral administration and subcutaneous injection; daily, for 5 days and weekly dosing
Result:	Increased human Ig on the surface of CD4+ and CD8+ T cells. Had free mAb in the serum of mice

References

[1] Ogura M, et, al. Oral treatment with foralumab, a fully human anti-CD3 monoclonal antibody, prevents skin xenograft rejection in humanized mice. Clin Immunol. 2017 Oct;183:240-246. DOI:10.1016/j.clim.2017.07.005

Supplier

Shanghai YuanYe Biotechnology Co., Ltd.

Telephone 15026964105

Websitehttps://www.shyuanye.com

ShangHai Biochempartner Co.,Ltd

Telephone177-54423994 17754423994

Websitehttps://www.biochempartner.com

Guangzhou Hongyuan Chemical Co.,Ltd

Telephone 15817493340

Websitehttps://www.chemicalbook.com/ShowSupplierProductsList1222417/0_EN.htm

Wuhan Chemstan Biotechnology Co., Ltd.

Telephone027-65317797 15926423062

Websitehttp://www.chemstan.com/

Beijing Jin Ming Biotechnology Co., Ltd.

Telephone010-60605840

Websitehttp://www.jm-bio.com/

TargetMol Chemicals Inc.

Telephone4008200310 15002144251

Websitehttps://www.targetmol.cn/

Biolab Reagents

Telephone027-65279366 18108604356

Websitehttps://www.biolabreagent.com/

Wuhan Jingkangen Biomedical Technology Co., Ltd

Telephone13720134139 086-15871494362 13720134139

Websitehttps://www.jknbiochem.com

Shanghai Yifei Biotechnology Co. , Ltd.

Telephone021-65675885 18964387627

Websitehttp://www.efebio.com

Wuhan Acumen Bio-Technology Co.,ltd

Telephone027-027-16602739303 16602739303

Websitehttp://www.yjybiochem.com/

Changsha Fuzhen Biotechnology Co.，LTD

Telephone15111215862 18229892877

Websitehttp://www.fuzhenbiochem.com/

Wanxin Biotechnology (Jiaxing) Co., LTD

Telephone0573-83568680 18057391398

Website

Atagenix Laboratories

Telephone027-87008169 17762441161

Websitehttps://www.abinscience.com/

Taizhou Zhongzhi Biotechnology Co., Ltd

Telephonezhongzhipharma@126.c 15066129350

Website

Wuhan Maixi Biotechnology Co., Ltd

Telephone18007167883 18007167883

Websitehttps://www.mabnus.cn

Shaanxi Didu Pharmaceutical Co., Ltd.

Telephone029-81124775 17791530730

Website

1of4

Related Products

Send Inquriy