Teplizumab
- Product NameTeplizumab
- CAS876387-05-2
- CBNumberCB48081201
- MW0
- MOL FileMol file
- MSDS FileSDS
Teplizumab Price
| Product number | Packaging | Price | Product description | Buy |
|---|---|---|---|---|
| ChemScene CS-0612899 | 1mg | $314 | Teplizumab 99.0% |
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| ChemScene CS-0612899 | 5mg | $948 | Teplizumab 99.0% |
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| ChemScene CS-0612899 | 10mg | $1517 | Teplizumab 99.0% |
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| ChemScene CS-0612899 | 25mg | $2437 | Teplizumab 99.0% |
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| ChemScene CS-0612899 | 50mg | $3629 | Teplizumab 99.0% |
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Teplizumab Chemical Properties,Usage,Production
Uses
Teplizumab (MGA-031) is a Fc receptor non-binding anti-human CD3 monoclonal antibody. Teplizumab reduces the loss of beta-cell function. Teplizumab can be used in the research of type 1 diabetes[1][2].in vivo
Teplizumab (0.24 mg/kg, i.p.) induces migration of human CD4 T cells to the lamina propria and ablated the treatment effects of the drug on graft survival in NSG mice[2].
| Animal Model: | NOD/SCID IL2γc-/- (NSG) mice (a tolergenic humanized mouse model)[1] |
| Dosage: | 0.24 mg/kg, 5 μg |
| Administration: | Intraperitoneal injection (i.p.) |
| Result: | Decreased CD4:CD8 ratio in the peripheral blood from 2.03 to 1.01, p < 0.05. Decreased circulating hCD4 cells in the peripheral blood. Decreased in the proportion of T cells in the bone marrow and lung. Increased in the total number of human CD45+ cells infiltrating the lamina propria of the small intestine. |
References
[1] Kevan C Herold, et al. An Anti-CD3 Antibody, Teplizumab, in Relatives at Risk for Type 1 Diabetes. N Engl J Med. 2019 Aug 15;381(7):603-613. DOI:10.1056/NEJMoa1902226[2] Frank Waldron-Lynch, et al. I Analysis of FcR non-binding anti-CD3 mAb in humanized mice identifies novel human gut tropic cells with regulatory function that are found in patients. Sci Transl Med. 2012 Jan 25;4(118):118ra12. DOI:10.1126/scitranslmed.3003401
[3] Brygida Bisikirska, et al. TCR stimulation with modified anti-CD3 mAb expands CD8+ T cell population and induces CD8+CD25+ Tregs. J Clin Invest. 2005 Oct;115(10):2904-13. DOI:10.1172/JCI23961
Preparation Products And Raw materials
Teplizumab Suppliers
Global(23)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| tp@aladdinsci.com | United States | 57505 | 58 | ||
| 1-631-485-4226; 16314854226 |
info@bocsci.com | United States | 9920 | 65 | |
| 13636370518 | shyysw007@163.com | China | 89686 | 60 | |
| 177-54423994 17754423994 |
2853530910@QQ.com | China | 7999 | 62 | |
| 15817493340 | 981810490@qq.com | China | 1578 | 58 | |
| 027-65317797 15926423062 |
422450190@qq.com | China | 10308 | 58 | |
| 400-1647117 13681763483 |
product02@bidepharm.com | China | 59936 | 58 | |
| 4008200310 15002144251 |
marketing@tsbiochem.com | China | 24959 | 58 | |
| 027-65279366 18108604356 |
products@biolabreagent.com | China | 9865 | 58 | |
| 021-65675885 18964387627 |
customer_service@efebio.com | China | 11972 | 58 |
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