ONO7475

Product NameONO7475
CAS1646839-59-9
CBNumberCB65867703
MFC32H26N4O6
MW562.57
MDL NumberMFCD32689448
MOL File1646839-59-9.mol

Chemical Properties

Boiling point	804.0±65.0 °C(Predicted)
Density	1.43±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml
form	A crystalline solid
pka	8.50±0.20(Predicted)
color	Light yellow to yellow
FDA UNII	0VCB95RHRV

ONO7475 Price

Product number	Packaging	Price	Product description	Buy
ChemScene CS-0083699	5mg	$250	ONO-7475 99.38%	Buy
ChemScene CS-0083699	10mg	$350	ONO-7475 99.38%	Buy
ChemScene CS-0083699	50mg	$780	ONO-7475 99.38%	Buy
DC Chemicals 013318	002	$950	ONO-7475	Buy
DC Chemicals 013318	003	$1900	ONO-7475	Buy

ONO7475 Chemical Properties,Usage,Production

Uses

Tamnorzatinib (ONO-7475) is a potent, selective, and orally active Axl/Mer inhibitor with IC50 values of 0.7 nM and 1.0 nM, respectively. Tamnorzatinib sensitizes AXL-overexpressing EGFR-mutant NSCLC cells to the EGFR-TKIs, suppresses the emergence and maintenance of tolerant cells. Tamnorzatinib combines with Osimertinib (HY-15772) provides a bright promise for the study of EGFR-mutated non-small cell lung cancer (NSCLC).

in vivo

Tamnorzatinib (oral gavage; 10 mg/kg or combines with 5 mg/kg Osimertinib; 29 days) treatment alone has little effect on the tumor growth. Besides, Osimertinib alone causes tumor regression within one week, but the tumors reappear within three weeks. The combined initial treatment causes tumor regression and the size of tumors is maintained for 4 weeks. No apparent adverse events, including weight loss are observed during these treatments^[1].

Animal Model:	Mouse CDX model using high-AXL-expressing PC-9KGR cells (exon 19 deletion and the exon21-T790M mutation in EGFR)^[1]
Dosage:	10 mg/kg; once daily; 19 days
Administration:	oral gavage
Result:	Had little effects alone, but combined treatments significantly decreased tumor volume without reappear.

IC 50

TrkA; Axl; Tyro3; Mer

References

[1] Okura N, et al. ONO-7475, a Novel AXL Inhibitor, Suppresses the Adaptive Resistance to Initial EGFR-TKI Treatment in?EGFR-Mutated Non-Small Lung Cancer.Clin Cancer Res.?2020 Jan 17. DOI:10.1158/1078-0432.CCR-19-2321
[2] Ruvolo PP, et al. Anexelekto/MER tyrosine kinase?inhibitor?ONO-7475?arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms.Haematologica.?2017 Dec;102(12):2048-2057. DOI:10.3324/haematol.2017.168856

Supplier	Tel	Email	Country	ProdList	Advantage
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19552	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32470	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39042	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Aladdin Scientific		tp@aladdinsci.com	United States	57505	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	orders@jknbiochem.com	China	5221	58
Sichuan Wei Keqi Biological Technology Co., Ltd.	028-81700200 18116577057	3003855609@qq.com	China	7778	56
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4797	55

ONO7475

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ONO7475 Chemical Properties,Usage,Production

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