名称 | ONO-7475 |
描述 | ONO-7475 is an inhibitor with high specificity for anexelekto and MER tyrosine kinase |
细胞实验 | Cell Line:High AXL-expressing cell: PC-9,HCC4011,H1975, PC-9KGR cells. Low AXL-expressing cell: HCC827, HCC4006, and H3255 cells. Concentration:0.0001 μM; 0.001 μM; 0.01 μM; 0.1 μM; 1 μM. Incubation Time:72 hours[1]. |
体外活性 | ONO-7475 sensitized AXL-overexpressing?EGFR-mutant NSCLC cells to the EGFR-TKIs osimertinib and dacomitinib. In addition, ONO-7475 suppressed the emergence and maintenance of EGFR-TKI-tolerant cells[2]. |
体内活性 | Mice fed a diet containing ONO-7475 exhibited significantly longer survival and, interestingly, blocked leukemia cell infiltration in the liver. In summary, ONO-7475 effectively kills acute myeloid leukemia cells?in vitro?and?in vivo?by mechanisms that involve disruption of diverse survival and proliferation pathways[1]. |
存储条件 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
溶解度 | DMSO : 100 mg/mL (177.76 mM)
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关键字 | lung | tumor | leukemia | inhibit | solid | ONO7475 | Trk Receptor | tolerant | cancer | Mer | Tropomyosin related kinase receptor | NSCLC | TAM Receptor | EGFR | ONO-7475 | ONO 7475 | Tyro3 | advanced | mutunt | Inhibitor | Axl | TKI | acute | metastatic |
相关产品 | UNC2025 | Gilteritinib | Bemcentinib | Larotrectinib sulfate | N-Acetyl-5-hydroxytryptamine | Selitrectinib | SP600125 | Amitriptyline hydrochloride | 7,8-Dihydroxyflavone | Diosmetin | GW 441756 | Cabozantinib S-malate |
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