Synthesis
GENERAL PROCEDURE: Isophthalamide (1.0 g, 9.3 mmol) was added to ethyl acetoacetate (1.2 eq, 2-3.6 g) and the mixture was heated to reflux for 20 hours. After completion of the reaction, the mixture was poured into ice (100 g) and the precipitate was collected by filtration. Purification by silica gel column chromatography (100-200 mesh, eluent methanol/chloroform, 1:99 v/v) afforded 7-amino-4-methylquinolin-2(1H)-one.
References
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[4] Bioorganic and Medicinal Chemistry, 2006, vol. 14, # 24, p. 8712 - 8728
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