Uses
Cardiac depressant (anti-arrhythmic).
Uses
Quinidine Gluconate is a salt of Quinidine (Q685000), a dextrorotatory stereoisomer of Quinine. Antiarrhythmic (class IA). Antimalarial.
Definition
ChEBI: Quinidine D-gluconate is a D-gluconate adduct. It is functionally related to a quinidine.
brand name
Duraquin (Warner Chilcott); Quinaglute (Berlex).
General Description
Quinidinium gluconate(Duraquin, Quinaglute) occurs as an odorless, very bitter,white powder. In contrast with the sulfate salt, it is freelysoluble in water. This is important because there are emergencieswhen the condition of the patient and the need for arapid response make the oral route of administration inappropriate.The high water solubility of the gluconate saltalong with a low irritant potential makes it valuable when aninjectable form is needed in these emergencies. Quinidinegluconate forms a stable aqueous solution. When used for injection, it usually contains 80 mg/mL, equivalent to 50 mgof quinidine or 60 mg of quinidine sulfate.
Veterinary Drugs and Treatments
Quinidine is used in small animal or equine medicine for the treatment
of ventricular arrhythmias (VPCs, ventricular tachycardia),
refractory supraventricular tachycardias, and supraventricular
arrhythmias associated with anomalous conduction in Wolff-
Parkinson-White (WPW) syndrome. Chronic use of quinidine for
controlling ventricular arrhythmias and supraventricular tachycardia
in dogs has diminished over the years as other drugs appear
to be more effective. It is still used in dogs and horses to convert
atrial fibrillation to sinus rhythm. Oral therapy is generally not
used in cats.
