Chemical Properties
Off-White Solid
Uses
Methylprednisolone acetate is used as a glucocorticoid.
Uses
6α-Methyl Prednisolone 21-Acetate is used as a glucocorticoid.
Definition
ChEBI: An acetate ester resulting from the formal condensation of the 21-hydroxy function of 6alpha-methylprednisolone compound with acetic acid.
brand name
Medrol (Pharmacia & Upjohn).
Biological Activity
Long-acting anti-inflammatory corticosteroid th at suppresses lymphocytes-mediated immunologic responses.
Methylprednisolone acetate (Depo-Medrol) is a long-acting anti-inflammatory corticosteroid th at suppresses lymphocytes-mediated immunologic responses. 6-Methylprednisolone acetate binds to intracellular glucocorticoid receptors and inhibits promoter domains of pro-inflammatory genes and hinders secretion of inflammatory cytokines. It effectively treats multiple ailments such as rheumatic and autoimmune diseases, leukemia, multiple myeloma, and Hodgkin's and non-Hodgkin's lymphoma symptoms along with other drugs. MPA improves COVID-19 pneumonia prognosis.
Toxics Screening Level
The initial threshold screening level (ITSL) for methylpredisolone acetate is 43 μg/m3 based on an annual averaging time.
