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Dexamethasone-17-acetate

Dexamethasone-17-acetate Structure
Dexamethasone-17-acetate
  • CAS No.1177-87-3
  • Chemical Name:Dexamethasone-17-acetate
  • CBNumber:CB9703269
  • Molecular Formula:C24H31FO6
  • Formula Weight:434.5
  • MOL File:1177-87-3.mol
Dexamethasone-17-acetate Property
Safety
  • Hazard Codes  :Xi
  • Risk Statements  :43
  • Safety Statements  :36/37
  • WGK Germany  :3
  • RTECS  :TU4050000
  • TSCA  :Yes
  • HS Code  :29372290
Hazard and Precautionary Statements (GHS)
  • Symbol(GHS)
  • Signal wordWarning
  • Hazard statements H317
  • Precautionary statements P280-P261-P280g-P302+P352a-P321-P333+P313-P501a
Dexamethasone-17-acetate Price More Price(16)
  • Brand: Sigma-Aldrich
  • Product number: 46166
  • Product name : Dexamethasone 21-acetate
  • Purity: VETRANAL
  • Packaging: 100mg
  • Price: $71.9
  • Updated: 2021/03/22
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  • Brand: Sigma-Aldrich
  • Product number: D0710000
  • Product name : Dexamethasone acetate
  • Purity: European Pharmacopoeia (EP) Reference Standard
  • Packaging: 
  • Price: $183
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Sigma-Aldrich
  • Product number: 1176506
  • Product name : Dexamethasone acetate
  • Purity: United States Pharmacopeia (USP) Reference Standard
  • Packaging: 200mg
  • Price: $366
  • Updated: 2021/03/22
  • Buy: Buy
  • Brand: Alfa Aesar
  • Product number: J63691
  • Product name : Dexamethasone acetate
  • Purity: 
  • Packaging: 5g
  • Price: $590
  • Updated: 2020/06/24
  • Buy: Buy
  • Brand: Alfa Aesar
  • Product number: J63691
  • Product name : Dexamethasone acetate
  • Purity: 
  • Packaging: 1g
  • Price: $163
  • Updated: 2020/06/24
  • Buy: Buy

Dexamethasone-17-acetate Chemical Properties,Usage,Production

  • Chemical Properties Off-White Solid
  • Originator Dexacen,Central,US,1977
  • Uses Protected Dexamethasone, a glucocorticoid anti-inflammatory agent.
  • Manufacturing Process The preparation of dexamethasone acetate is described in US Patent 3,007,923 as follows. 1.5 cc of dimethylformamide and 1.5 cc of anhydrous hydrofluoric acid are admixed and treated with 480 mg of 9β,11β-epoxy-17αhydroxy-21-acetoxy-16α-methyl-?1,4-pregnadiene-3,20-dione (prepared according to E.P. Oliveto et al, J. Am. Chem. Soc., 80, 44331, 1958). The steroid dissolves in about 15 minutes. The reaction mixture is shaken for two hours at a temperature between 0 and +5°C, and then poured into 75 cc of
    water containing in suspension, 7.5 grams of sodium bicarbonate. The mixture is vacuum filtered, the filter cake washed and then dried at 100°C, yielding 460 mg of crude hexadecadrol contaminated with a small amount of the starting material. A single recrystallization from methylene chloride yields 370 mg of the pure product having a melting point of 170°C and 229°C. The mother liquor yields 62 mg of the starting material, and a remainder constituting a mixture of starting and final materials with little other contamination.
  • brand name Decadron (Merck).
  • Therapeutic Function 9-Fluoro-11β,17-dihydroxy-21-acetoxy-16α-methylpregna1,4-diene-3,20-dione
  • Safety Profile Experimental teratogenic and reproductive effects. A steroid. When heated to decomposition it emits toxic fumes of F-.
  • Purification Methods Dexamethasone 21-acetate is purified on neutral Al2O3 using CHCl3 as eluent, the fractions are evaporated, and the residue is recrystallised from CHCl3. It has max at 239nm. [Oliveto et al. J Am Chem Soc 8 0 4431 1958]. [Beilstein 8 IV 3501.]
Dexamethasone-17-acetate Preparation Products And Raw materials
Raw materials
Preparation Products
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1177-87-3, Dexamethasone-17-acetateRelated Search:
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  • Dexametasone acetate
  • MPB Dexamethasone-21-acetate
  • 21-O-Acetyl Dexamethasone
  • 9α-Fluoro-16α-methylprednisolone-21-acetate, Prednisolone F acetate
  • Dexamethasone 21-acetate,9α-Fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione-21-acetate, 9α-Fluoro-16α-methylprednisolone-21-acetate, Prednisolone F acetate
  • Dexamethasone Acetate (200 mg)
  • Dexamethasone Acetate (200 mg)H0E3390.996mg/mg(dr)
  • Dexamethasone-17-ace
  • 9-ALPHA -FLUORO-11BETA 17ALPHA 21-TRIHYDROXY-16ALPHA -METHYL-1 4-PREGNADIENE-3 20-DIONE
  • 2-((8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-10,13,16-triMethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
  • Dexamethasone 21-Acetate Solution, 100ppm
  • Dexamethasone Acetate Dexamethasoneacetate dexamethasone-21-acetate
  • DEXAMETHASON ACETATE
  • dexamethasone-17-acetate
  • DEXAMETHASONE 21-ACETATE
  • DEXAMETHASONE ACETATE
  • 1,4-PREGNADIEN-9-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA, 17,21-TRIOL-3,20-DIONE 21-ACETATE
  • PREDNISOLONE F ACETATE
  • 9ALPHA-FLUORO-16ALPHA-METHYL-11BETA,17ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE-21-ACETATE
  • 9-ALPHA-FLUORO-16-ALPHA-METHYL-11-BETA,17-ALPHA,21-TRIHYDROXY-1,4-PREGNADIENE-3,20-DIONE ACETATE
  • 9ALPHA-FLUORO-16ALPHA-METHYLPREDNISOLONE-21-ACETATE
  • 9 ALPHA-FLUORO-11 BETA,17 ALPHA,21-TRIHYDRO-16 ALPHA-METHYLPREGNA-1,4-DIENE-3,20-DIONE-21-ACETATE
  • 9a-fluoro-16a-methyl-11b,17a,21-trihydroxy-1,4-pregnadiene-3,20-dione-21-acetate
  • Panasone
  • Pregna-1,4-diene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-16-methyl-, (11beta,16alpha)-
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-16alpha-methyl-, 21-acetate
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-16alpha-methyl-, acetate
  • DEXAMETHASON 21-ACETATE VETRANAL, 250 MG
  • DEXAMETHASONE ACETATE EPD(CRM STANDARD)
  • DEXAMETHASONE ACETATE USP(CRM STANDARD)
  • DEXAMETHASONE ACETATE WHO(CRM STANDARD)
  • DEXAMETHASONE 21-ACETATE, USP
  • 9α-fluoro-16α-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione-21-acetate
  • DEXAMETHASONEACETATE,ANHYDROUS,MICRONIZED,USP
  • 16α-Methyl-9α-fluoroprednisolone 21-acetate
  • NSC 39471