Uses
Diethyl Methylsulfinylmethylphosphonate is used for the preparation of vinyl sulfoxides and O,S-acetals of formyl phosphonates.
Preparation
Diethyl methylsulfinylmethylphosphonate can be obtained by controlled oxidation of Diethyl Methylthiomethylphosphonate, as shown in eq 1. The procedure using Br2/aq. NaHCO3/CH2Cl2 is notable because use of H
218O allows for the preparation of
18O sulfoxides.
storage
Diethyl Methylsulfinylmethylphosphonate is reasonably stable for storage. Reactions involving this reagent are best conducted under anhydrous conditions, under nitrogen, in a well ventilated fume hood.
