Diethyl Methylsulfinylmethylphosphonate is used for the preparation of vinyl sulfoxides and O,S-acetals of formyl phosphonates.
Preparation
Diethyl methylsulfinylmethylphosphonate can be obtained by controlled oxidation of Diethyl Methylthiomethylphosphonate, as shown in eq 1. The procedure using Br2/aq. NaHCO3/CH2Cl2 is notable because use of H218O allows for the preparation of 18O sulfoxides.
storage
Diethyl Methylsulfinylmethylphosphonate is reasonably stable for storage. Reactions involving this reagent are best conducted under anhydrous conditions, under nitrogen, in a well ventilated fume hood.
