50746-61-7

Diethyl Methylsulfinylmethylphosphonate is used for the preparation of vinyl sulfoxides and O,S-acetals of formyl phosphonates.

Diethyl methylsulfinylmethylphosphonate can be obtained by controlled oxidation of Diethyl Methylthiomethylphosphonate, as shown in eq 1. The procedure using Br2/aq. NaHCO3/CH2Cl2 is notable because use of H₂¹⁸O allows for the preparation of ¹⁸O sulfoxides.

Diethyl Methylsulfinylmethylphosphonate is reasonably stable for storage. Reactions involving this reagent are best conducted under anhydrous conditions, under nitrogen, in a well ventilated fume hood.