Description
Prostaglandin E
2 methyl ester (PGE
2 methyl ester) is an analog of PGE
2 with enhanced lipid solubility. PGE
2 is one of the primary cyclooxygenase products of arachidonic acid and one of the most widely investigated PGs. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation. The effects of PGE
2 are transduced by at least four distinct receptors designated EP
1, EP
2, EP
3, and EP
4. Affinity constants (K
d) values of PGE
2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.
