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Prostaglandin E₂ methyl ester (PGE₂ methyl ester) is an analog of PGE₂ with enhanced lipid solubility. PGE₂ is one of the primary cyclooxygenase products of arachidonic acid and one of the most widely investigated PGs. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation. The effects of PGE₂ are transduced by at least four distinct receptors designated EP₁, EP₂, EP₃, and EP₄. Affinity constants (K_d) values of PGE₂ for these receptors range from 1-10 nM depending on the receptor subtype and tissue.

Prostaglandin E2 methyl ester (PGE2 methyl ester) is an lipophilic derivative analog of PGE2 (HY-101952). Prostaglandin E2 methyl ester has more central penetration ability than PGE2[1].

[1] Strand JC, et al. Biological activity of the methyl esters of prostaglandin E2 and its (15S)-15-methyl analogue. Eur J Pharmacol. 1974 May;26(2):151-7. DOI:10.1016/0014-2999(74)90221-0