Description
9(S)-
HODE is produced by the lipoxygenation of linoleic acid in both plants and animals. It has been detected in atherosclerotic plaques, as an esterified component of membrane phospholipids and in oxidized LDL particles.
Uses
9S-HODE (Alpha-dimorphecolic acid) is an octadecadienoic acid and the main active derivative of linoleic acid, which can reduce the viability of HL-60 cells and induce apoptosis. 9S-HODE is rich in lipid peroxidation (LPO) products and is almost an ideal marker for LPO[1][2].
Definition
ChEBI: A 9-HODE in which the 9-hydroxy group has S-stereochemistry.
IC 50
Human Endogenous Metabolite
References
[1] Liu S, et al. Linoleic acid derivatives target miR-361-3p/BTG2 to confer anticancer effects in acute myeloid leukemia. J Biochem Mol Toxicol. 2023 Nov;37(11):e23481. DOI:
10.1002/jbt.23481[2] Spiteller P, et al. 9-Hydroxy-10, 12-octadecadienoic acid (9-HODE) and 13-hydroxy-9, 11-octadecadienoic acid (13-HODE): excellent markers for lipid peroxidation[J]. Chemistry and Physics of Lipids, 1997, 89(2): 131-139.
