SESELIN

Product NameSESELIN
CAS523-59-1
CBNumberCB61444407
MFC14H12O3
MW228.24
MDL NumberMFCD01018179
MOL File523-59-1.mol
MSDS FileSDS

Chemical Properties

Melting point	119-124 °C
Boiling point	403.0±45.0 °C(Predicted)
Density	1.351 g/cm3(Temp: 18 °C)
storage temp.	Store at -20°C
solubility	Soluble in DMSO
form	A solid
color	White to off-white
InChI	1S/C14H12O3/c1-14(2)8-7-10-11(17-14)5-3-9-4-6-12(15)16-13(9)10/h3-8H,1-2H3
InChIKey	QUVCQYQEIOLHFZ-UHFFFAOYSA-N
SMILES	[o]1c2c(ccc3c2C=CC(O3)(C)C)cc[c]1=O
FDA UNII	5634E8957P
UNSPSC Code	12352200
NACRES	NA.77

Safety

WGK Germany	WGK 3
Storage Class	11 - Combustible Solids

SESELIN Price

Product number	Packaging	Price	Product description	Buy
Cayman Chemical 29930	1mg	$153	Seselin	Buy
Cayman Chemical 29930	5mg	$456	Seselin	Buy
TRC S280650	5mg	$360	Seselin	Buy
TRC S280650	10mg	$685	Seselin	Buy
American Custom Chemicals Corporation PXT0001956	5MG	$496.49	SESELIN 95.00%	Buy

SESELIN Chemical Properties,Usage,Production

Uses

Seselin is a coumarin compound that can be isolated from the root bark of the Citropsis articulata plant. Studies show that Seselin might exhibit potential antimalarial activity and that its derivatives may exhibit antithrombotic activity.

Definition

ChEBI: A natural product found in Citropsis articulata.

Biological Activity

Seselin is an anti-inflammatory, anti-parasitic and antifungal pyrancoumarin found in anise and other plants. It appears th at seselin targets Jak2 to block the proinflammatory phenotype of macrophages in models of sepsis. Seselin down-regulates levels of proinflammatory factors and activity of STAT1 and p65 in models of sepsis.

in vivo

Seselin (0.5-40.5 mg/kg; s.c.; once) shows peripheral anti-inflammatory and antinociceptive activities in mice^[2].
Seselin (3-30 mg/kg; i.g.; once) ameliorates sepsis induced by caecal ligation and puncture in mice^[3].

Animal Model:	Male Swiss mice^[2]
Dosage:	0.5, 4.5 or 40.5 mg/kg
Administration:	Subcutaneous injection; once
Result:	Inhibited the writhing response induced by acetic acid in a significant and dose-dependent manner, by 19.5%, 26.2% and 41.4% at dose of 0.5, 4.5 or 40.5 mg/kg, respectively. Elicited a significant inhibition of formalin response during the second phase (inflammatory), by 90.3%, 97.8% and 95.3%, respectively.

Animal Model:	C57BL/6 mice, caecal ligation and puncture (CLP) induced sepsis model^[3]
Dosage:	3, 10 and 30 mg/kg
Administration:	Intragastric administration, once
Result:	Ameliorated lung injury and decreased JAK2 phosphorylation level in lung tissue during sepsis. Reduced the immune cell counts in BALF induced by CLP.

Supplier	Tel	Email	Country	ProdList	Advantage
Chengdu Biopurify Phytochemicals Ltd.	+86-28-82633860; +8618080483897	sales@biopurify.com	China	3751	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569266 +86-17392581500	1015@dideu.com	China	3986	58
Wuhan ChemNorm Biotech Co.,Ltd.	+86-27-8439 4403 18971486879	sales@chemnorm.com	CHINA	2935	58
TargetMol Chemicals Inc.	+1-781-999-5354; +17819995354	marketing@targetmol.com	United States	32470	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
TargetMol Chemicals Inc.	+1-781-999-5354;	support@targetmol.com	United States	39043	58
GIHI CHEMICALS CO.,LIMITED	+86-571-86217390; +8618058761490	info@gihichemicals.com	China	49964	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42056	58
Aladdin Scientific		tp@aladdinsci.com	United States	52923	58
Mensura Group Limited	18780014153	1058503172@qq.com	China	2900	58

SESELIN

Chemical Properties

Safety

SESELIN Price

SESELIN Chemical Properties,Usage,Production

Preparation Products And Raw materials

SESELIN Suppliers

View Lastest Price from SESELIN manufacturers

SESELIN Spectrum

523-59-1, SESELINRelated Search