Metabolic pathway
In the feces and urine of rats, more than 90% of
administered 14C-flumiclorac pentyl is excreted within
48 h of treatment. Flumiclorac pentyl is rapidly and
extensively metabolized. The major fecal metabolites
are identified as the sulfonic acid conjugates, and the
major urinary metabolite is identified as 5-amino-2-
chloro-4-fluorophenoxyacetic acid. The metabolic
reactions include cleavage of the ester linkage, cleavage
of the imide linkage, hydroxylation and following
reduction at the cyclohexene ring of the cyclohexene-
1,2-dicarboxylic acid moiety, and incorporation of a
sulfonic acid group into the carbon ? carbon double bond
of the 3,4,5,6-tetrahydrophthalimide moiety.
