Originator
Baycaron,Bayer,W. Germany,1967
Uses
Mefruside is a diuretic used for the treatment of edema and hypertension.
Definition
ChEBI: Mefruside is an organic molecular entity.
Manufacturing Process
By hydrogenation of α-methyl-α-cyanotetrahydrofuran with Raney nickel as catalyst, α-methyl-α-tetrahydrofurfuryl amine is obtained (BP 48°C/12 mm Hg) which is alkylated by dimethyl sulfate to give α-methyl-αtetrahydrofurfurylmethylamine (BP 70°C/40 mm Hg). The amine is then reacted with 4-chloro-3-sulfamyl benzene sulfochloride in the presence of an acid acceptor. The mixture is stirred overnight, the solvent (acetone or pyridine) is driven off under vacuum and the residue is recrystallized from alcohol.
Therapeutic Function
Diuretic
