Uses
Tipelukast a novel oral anti-inflammatory agent, suppresses bladder hyperactivity in a rat model.
Definition
ChEBI: Tipelukast is an aromatic ketone.
Biological Activity
Tipelukast is a Leukotriene D4 (LTD4) receptor antagonist and an inhibitor of 5-lipoxygenase (5-LO) and also phosphodiesterases PDE3 and PDE4. It has been found to have antifibrotic and anti-inflammatory activity. Tipelukast has been investigated as a possible treatment for nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH).
