Uses
Sulfuretin inhibits the inflammatory response by suppressing the NF-κB pathway. Sulfuretin can be used for the research of allergic airway inflammation. Sulfuretin reduces oxidative stress, platelet aggregation, and mutagenesis[1]. Sulfuretin is a competitive and potent inhibitor of monophenolase and diphenolase activities with the IC50 of 13.64 μM[2].
Definition
ChEBI: Sulfuretin is a member of 1-benzofurans.
Biological Activity
Anti-adipogenic, antineoplastic activity, antioxidative stress, Anti-Inflammatory
in vivo
Sulfuretin inhibits the inflammatory responses by suppressing the NF-κB pathway in type 1 diabetes models. Sulfuretin (40 μg/kg; single intraperitoneal injection 2 h after the last OVA challenge) suppresses ovalbumin (OVA)-induced chemotaxis and airway inflammation[1].
| Animal Model: | Pathogen-free male BALB/c mice (7-8 weeks old)[1] |
| Dosage: | 40 μg/kg |
| Administration: | A single intraperitoneal injection was administered 2 h after the last OVA challenge |
| Result: | Suppressed OVA-induced chemotaxis and airway inflammation.
|
References
[1] Mi-Young Song, et al. Sulfuretin attenuates allergic airway inflammation in mice. Biochem Biophys Res Commun. 2010 Sep 10;400(1):83-8. DOI:
10.1016/j.bbrc.2010.08.014[2] Chen, H., et al. Isolation of sulfuretin and butin from Rhus verniciflua Stokes using medium-pressure liquid chromatography and their tyrosinase inhibitory effects. BioRes. 11(1), 759-771.
[3] SO YOUNG KANG Myung J O Ji Young Kang. Antiviral activities of flavonoids isolated from the bark of Rhus verniciflua stokes against fish pathogenic viruses In Vitro.[J]. Journal of Microbiology, 2012, 50 2: 293-300. DOI:
10.1007/s12275-012-2068-7
