Chemical Properties
Off-white crystalline powder
Uses
3,4-Dihydro-2(1
H)-quinolinone may be employed as medium supplement in the culture medium of
Pseudomonas ayucida during enrichment culture experiments.
Uses
3,4-Dihydro-2-(1H)-quinolinone may be employed as medium supplement in the culture medium of Pseudomonas ayucida during enrichment culture experiments. It is used to prepare potent bicyclic peptide deformylase inhibitors with antibacterial effects. It is also used to synthesize substituted iminopiperidines as inhibitors of human nitric oxide synthase isoforms.
Definition
ChEBI: 3,4-Dihydro-2(1H)-quinolinone is a member of quinolines.
General Description
Series of 3,4-dihydro-2(1
H)-quinolinone derivatives having sigma-1 receptor (σ1R) antagonist activity have been synthesized. 3,4-dihydro-2((1)
H)-quinolinones have been synthesized using
N-(1′-alkoxy)cyclopropyl-2-haloanilines as starting reagent. Cyclopropane ring expansion in the presence of palladium catalyst is the major step involved in the synthesis. Library of 3,4-dihydro-2(1
H)-quinolinones have been synthesized through the rearrangement of β-lactam intermediates on the solid-phase
