Description
19(R)-hydroxy PGF
2α is an ω-1 hydroxylase metabolite of PGF
2α found in human semen. The concentration of 19(R)-hydroxy PGF compounds (F
2α and F
1α together) in fresh human semen is about 20 μg/ml.
1 19(R)-hydroxy PGF
2α exhibits no activity at the FP receptor of the cat iris sphincter muscle at concentrations up to 1 μM.
2
References
1. Taylor, P.L., and Kelly, R.W.
The occurrence of 19-hydroxy F prostaglandins in human semen FEBS Lett. 57(1),22-25(1975).
2. Woodward, D.F., Protzman, C.E., Krauss, A.H.P., et al.
Identification of 19(R)-OH prostaglandin E2 as a selective prostanoid EP2-receptor agonist Prostaglandins 46(4),371-383(1993).
