SNAP

Chemical Properties

Green Crystalline Solid

Uses

The D-isomer of SNAP. Serves as an NO donor.

Definition

ChEBI: A nitroso compound that is N-acetyl-D-penicillamine in which the sulfanyl hydrogen is replaced by a nitroso group.

General Description

Nitric oxide donor that begins to evolve nitric oxide immediately upon solubilization in aqueous buffers (t_1/2 = 10 h). Mimics the actions of nitric oxide, including the relaxation of isolated bovine coronary artery rings (EC₅₀ = 130 nM). Markedly activates soluble guanylate cyclase. Also reported to cause the reversible inactivation of protein kinase C activity. Induces apoptosis in mouse thymocytes. Note: 1 set = 4 x 5 mg.

Biological Activity

A stable analog of endogenous S-nitroso compounds. A source of NO in vivo which unlike organic O-nitrates does not induce tolerance. Decomposes slowly in solution with a t ?of 37h.

Biochem/physiol Actions

EC50 = 130 nM in relaxation of isolated bovine coronary artery rings

storage

Store at -20°C