Description
SNAP is an S-
nitrosothiol which serves as a NO donor and a potent vasodilator. Its stability in solution varies from seconds to hours depending on temperature, buffer composition and metal content. At pH 6-
8 and 37°C, the half-
life of SNAP is approximately six hours in the presence of transition metal ion chelators.
Chemical Properties
2-acetamido-3-methyl-3-(nitrososulfanyl)butanoic acid is green crystalline solid
Uses
Produced concentration-related relaxations of mouse anococcygeus, in a range similar to that already found for NO and other nitrovasodilators. A potent relaxant of non-vascular smooth muscle. Serves as an NO donor.
Biochem/physiol Actions
NO donor; vasodilator, smooth muscle relaxant, lymphocyte activator. Activates soluble guanylyl cyclase.
