3,5-BIS(1,1-DIMETHYLETHYL)-4-HYDROXY-ALPHA,ALPHA-DIMETHYLBENZENEPROPANAL

Uses

CGP 13501 is a positive allosteric modulator at GABAB?receptors.

Definition

ChEBI: 3-(3,5-ditert-butyl-4-hydroxyphenyl)-2,2-dimethylpropanal is an alkylbenzene.

Biological Activity

Positive allosteric modulator of GABA B receptors, potentiating the effects of GABA at this receptor type.

References

[1]. urwyler s, mosbacher j, lingenhoehl k, et al. positive allosteric modulation of native and recombinant gamma-aminobutyric acid(b) receptors by 2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (cgp7930) and its aldehyde analog cgp13501. mol pharmacol, 2001, 60(5): 963-971.
[2]. rasheed n, ahmad a, al-sheeha m, et al. neuroprotective and anti-stress effect of a68930 in acute and chronic unpredictable stress model in rats. neurosci lett, 2011, 504(2): 151-155.