Description
1,1,1-Trifluoro-4-iodobutane is an organic compound with the chemical formula CIF3. It is a colorless liquid that reacts with water and alcohol to form hydrogen fluoride and hydrofluoric acid. 1,1,1-Trifluoro-4-iodobutane is a potent sensitizer that can irritate the skin and eyes. It has been used experimentally as a solvent for diethyl ether in the synthesis of piperidinium salts. The cavity viscosity of 1,1,1-trifluoro-4-iodobutane has been measured at room temperature and found to be 0.0038 Pa·s at 25 °C. In laboratory tests, this molecule has shown antibacterial activity against Propionibacterium acnes (P. acnes) and Staphylococcus aureus (S. aureus).
Uses
1,1,1-Trifluoro-4-Iodobutane can be used to prepare small molecule inhibitors of SLC15A4 possessing anti-inflammatory activity.
Synthesis
In a 1.0 L reactor add 0.8 g of 18-crown-6, 3 mol of CF3CH2CH2CH2Cl, 1.5 mol of potassium iodide and
After 500 ml of acetone, the reactor was sealed. With stirring on, the reactor was warmed up to 90 C and reacted at a constant temperature for 6
h. The reactants were filtered and distilled to give CF3CH2CH2CH2CH2I in 93.4% yield based on potassium iodide.
