2-Propyl-4-pentenoic acid

Description

(±)-2-propyl-4-Pentenoic acid (4-ene VPA) is a major metabolite of valproic acid . It undergoes β-oxidation to form reactive metabolites that induce hepatotoxicity in rats. 4-ene VPA is also neuroteratogenic, reducing forebrain size and inducing deformation of the neural tube in mouse embryos.

Chemical Properties

Clear Colorless Oil

Uses

A metabolite of Valproic Acid

Definition

ChEBI: 2-n-Propyl-4-pentenoic acid is a methyl-branched fatty acid.

Hazard

Moderately toxic.

References

[1] W TANG  F S A. A comparative investigation of 2-propyl-4-pentenoic acid (4-ene VPA) and its alpha-fluorinated analogue: phase II metabolism and pharmacokinetics.[J]. Drug Metabolism and Disposition, 1997, 25 2: 219-227.
[2] F. GOFFLOT . In vitro neuroteratogenicity of valproic acid and 4-en-VPA[J]. Neurotoxicology and teratology, 1995, 17 4: Pages 425-435. DOI: 10.1016/0892-0362(94)00094-t