Description
Hederagenin is a triterpene saponin that has been found in
P. eximia with diverse biological activities. It increases production of reactive oxygen species (ROS), reduces colony formation, and induces apoptosis in cisplatin-resistant head and neck carcinoma (HNC) cells.
In vivo, hederagenin (50, 100, and 200 mg/kg) suppresses tumor growth in a cisplatin-resistant HNC mouse xenograft model. It reduces aortic atherosclerotic lesion area, serum cholesterol and LDL levels, and inducible nitric oxide synthase (iNOS) protein levels in a rat model of atherosclerosis. Hederagenin (50 mg/kg) reduces ethanol-induced production of TNF-α, IL-6, and COX-2, alcohol dehydrogenase 2 (ALDH2) mRNA expression, and liver damage in a rat model of alcohol-induced hepatotoxicity. It also induces autophagy and inhibits oligomerization of α-synuclein in a mouse model of Parkinson''s disease induced by MPTP.
Chemical Properties
White Solid
Uses
Triterpenoid which can inhibit the proliferation of leukemia HL-60 cells.
Definition
ChEBI: A sapogenin that is olean-12-en-28-oic acid substituted by hydroxy groups at positions 3 and 23 (the 3beta stereoisomer).
in vivo
Hederagenin (25 mg/kg; po; 11 d) alone did not affect tumor growth in NCI-H1299 xenograft mice. However, it has a synergistic effect with Cisplatin (1 mg/kg) to inhibit tumor growth[4].
Hederagenin (50 mg/kg; po; once daily for 21 days) exerts anti-inflammatory and anti-apoptotic activities and reduces liver damage induced by 25% ethanol in mice[5].
References
[1] LALITH JAYASINGHE . Hederagenin glycosides from Pometia eximia[J]. Phytochemistry, 1995, 40 3: Pages 891-897. DOI:
10.1016/0031-9422(95)00360-j[2] EUN HYE KIM. Hederagenin Induces Apoptosis in Cisplatin-Resistant Head and Neck Cancer Cells by Inhibiting the Nrf2-ARE Antioxidant Pathway.[J]. Oxidative Medicine and Cellular Longevity, 2017: 5498908. DOI:
10.1155/2017/5498908[3] SU-HONG LU. Experimental Study of Antiatherosclerosis Effects with Hederagenin in Rats[J]. Evidence-based Complementary and Alternative Medicine, 2015, 35 1. DOI:
10.1155/2015/456354[4] GYEONG-JI KIM. Hederagenin Supplementation Alleviates the Pro-Inflammatory and Apoptotic Response to Alcohol in Rats[J]. Nutrients, 2017. DOI:
10.3390/nu9010041[5] AN-GUO WU . Hederagenin and α-hederin promote degradation of proteins in neurodegenerative diseases and improve motor deficits in MPTP-mice[J]. Pharmacological research, 2017, 115: Pages 25-44. DOI:
10.1016/j.phrs.2016.11.002
