Uses
Crystalline reagent for peptide coupling of a-alkylated N-Fmoc and N-Z-amino acids in high yield and without racemization.
Uses
Reagent for:
Peptide coupling reactions and synthesis of coupling reagents
Sequence selective peptide recognition
Synthesis of condensing reagents
Synthesis of heterocyclic β-sheet ligands
Preparation
Preparation of chlorotripyrrolidinophosphonium hexafluorophosphate: addition of chlorine to a diethyl ether solution of tripyrrolidinophosphine, then addition of KPF6 in water. Addition of tripyrrolidinophosphine oxide to a DCM solution of phosphoryl trichloride, then addition of KPF6 in water.
reaction suitability
reaction type: Coupling Reactions
