Description
Valeric anhydride is an important organic synthetic raw material or intermediate component, often used in industrial or medical fields. It can be used in the preparation of butylphthalide, resin components, lutein esters, analgesics and organic glass.
Chemical Properties
clear colorless to yellow liquid
Uses
Valeric anhydride can be used as a reactant to synthesize:
- Alkyl 9-nitrocamptothecin esters by the esterification reaction.
- Modified bismuth metal-organic frameworks (Bi-MOFs).
- O-acylated chitosan nanofibers (CSNFs) for potential usage in biomaterials and food packaging.
Uses
Valeric Anhydride is used in the synthesis of non-imadazole histamine H3-antagonists. Also used in the preparation of millepachine derivatives as a new class of tubulin polymerization inhibitors.
Preparation
Valeric anhydride was obtained by a treatment of the anhydrous sodium valerate by acid chloride of valeric acid
[1].
Hazard
Valeric anhydride is a colourless liquid that is corrosive and irritant. Contact may lead to severe eye irritation. Skin contact may cause severe skin burns and may also trigger allergic skin reactions.
Flammability and Explosibility
Non flammable
References
[1] T. S. Kotel’nikova. (2009). Kinetics of alcoholysis of valeric anhydride by cyclohexanol in the presence of formic acid. Russian Journal of Applied Chemistry, 82 3, 466–472. https://doi.org/
10.1134/S1070427209030227
